Phenylketonuria (PKU), a genetic condition, arises from insufficient phenylalanine hydroxylase (PAH) enzyme activity.
The PAH enzyme metabolizes the amino acid phenylalanine into tyrosine. Insufficient PAH function results in elevated, toxic phenylalanine levels in the body, causing significant intellectual impairment, developmental delays, and other neurological issues if left unmanaged. Dietary restriction of phenylalanine is the standard treatment for PKU.
A diseased man marries a normal woman. They get three daughter and five sons. All the daughter were diseased and sons were normal.The gene of this disease is