Question:medium
Pegloticase is used for the treatment of:
Pegloticase is used for the treatment of:
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Think of the drug that enzymatically dissolves uric acid in deposit-heavy disease.
Updated On: Jun 23, 2026
- Reactive arthritis
- CPPD (calcium pyrophosphate deposition disease)
- Chronic tophaceous gout
- Refractory rheumatoid arthritis
Show Solution
The Correct Option is C
Solution and Explanation
Clinical pearl: drugs ending in '-ase' here point to an enzyme. Pegloticase is a uricase that chews up uric acid directly, so it belongs to gout, not to any other arthritis on the list.
Pegloticase oxidises urate to allantoin, a far more soluble product that the kidney clears easily. Because it is given intravenously and carries infusion-reaction and anti-drug-antibody risk, it sits as a third-line option only for severe refractory chronic gout with large tophi after oral agents fail.
Option-elimination: reactive arthritis and rheumatoid arthritis are inflammatory but not crystal-driven by urate, so a uricase has no role. CPPD deposits calcium pyrophosphate, not monosodium urate, so lowering urate does nothing. That leaves chronic tophaceous gout as the only urate-deposition disease, the right answer.
Pegloticase oxidises urate to allantoin, a far more soluble product that the kidney clears easily. Because it is given intravenously and carries infusion-reaction and anti-drug-antibody risk, it sits as a third-line option only for severe refractory chronic gout with large tophi after oral agents fail.
Option-elimination: reactive arthritis and rheumatoid arthritis are inflammatory but not crystal-driven by urate, so a uricase has no role. CPPD deposits calcium pyrophosphate, not monosodium urate, so lowering urate does nothing. That leaves chronic tophaceous gout as the only urate-deposition disease, the right answer.
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