Question

PDE 4 inhibitor used in COPD

• A. Montelukast
• B. Roflumilast
• C. Cromoglicate
• D. Omalizumab

Hint:

PDE4 inhibitors like roflumilast help control inflammation in COPD by modulating intracellular signaling pathways, improving symptoms and reducing exacerbations.

Answer 1

The Correct Option is B

PDE4 inhibitors work by keeping cyclic AMP levels high inside inflammatory cells, which reduces inflammation in the airway. Only one of the four drugs here uses this mechanism.

1. Montelukast: Works on leukotriene receptors instead, a pathway used mostly in asthma control.
2. Roflumilast: Selectively blocks PDE4, raising cAMP and lowering the release of inflammatory chemicals in lung tissue, and is used specifically to cut flare-ups in severe COPD.
3. Cromoglicate: Stabilizes mast cells so they release fewer inflammatory chemicals, useful in preventing asthma attacks but unrelated to PDE4.
4. Omalizumab: An antibody that mops up circulating IgE, used in severe allergic asthma, again with no PDE4 activity.

The PDE4-blocking, COPD-approved drug among these four is roflumilast.

So the correct answer is Roflumilast.