Question

Pathological manifestation of chronic alcoholism includes all of the following except -

• A. Piecemeal necrosis
• B. Ballooning degeneration
• C. Microvesicular fatty changes
• D. Central hyaline sclerosis

Hint:

Which change marks chronic active hepatitis at the portal interface, not alcohol injury?

Answer 1

The Correct Option is A

Step 1: The task is to find the odd one out among liver changes. List what alcohol actually does to the liver and then see which option is foreign to that list.

Step 2: Alcohol first causes fatty change that begins microvesicular, validating microvesicular fatty change. In the hepatitis stage it causes swollen ballooned hepatocytes, so ballooning degeneration belongs. Fibrosis hugging the central vein produces central hyaline sclerosis, so that belongs too.

Step 3: Now place piecemeal necrosis. It refers to lymphocytic erosion of hepatocytes at the portal limiting plate, the defining lesion of chronic active hepatitis from viral or autoimmune causes. Alcohol injury centres on the perivenular zone, not the portal interface.

Step 4: Since piecemeal necrosis is a marker of chronic hepatitis rather than alcoholic liver disease, it is the exception asked for.

\[\boxed{\text{Piecemeal necrosis}}\]