Question:medium
Paget's disease is associated with which other cancer?
Paget's disease is associated with which other cancer?
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Extramammary Paget's disease loves apocrine-gland-rich skin of the external genitalia.
Updated On: Jun 23, 2026
- Vulva
- Vagina
- Cervix
- Uterus
Show Solution
The Correct Option is A
Solution and Explanation
Step 1: Identify the disease type. Paget's disease outside the breast - extramammary Paget's disease - is an intraepithelial adenocarcinoma that favours skin loaded with apocrine glands.
Step 2: In gynaecology the apocrine-rich skin is the vulva, so this is where EMPD characteristically develops, typically in older women as a persistent, itchy, red plaque with white scaling that mimics dermatitis but fails to clear.
Step 3: Rule out the alternatives. The vagina, cervix and uterus are mucosal, non-apocrine surfaces and are not classic sites for Paget's disease. Therefore the matched cancer site is the vulva. \[\boxed{\text{Vulva}}\]
Step 2: In gynaecology the apocrine-rich skin is the vulva, so this is where EMPD characteristically develops, typically in older women as a persistent, itchy, red plaque with white scaling that mimics dermatitis but fails to clear.
Step 3: Rule out the alternatives. The vagina, cervix and uterus are mucosal, non-apocrine surfaces and are not classic sites for Paget's disease. Therefore the matched cancer site is the vulva. \[\boxed{\text{Vulva}}\]
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