Question:easy
Nitric oxide acts by increasing:
Nitric oxide acts by increasing:
Show Hint
NO stimulates guanylate cyclase to make which messenger?
Updated On: Jun 24, 2026
- BRCA 1
- BRCA 2
- Interleukin
- cGMP
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The Correct Option is D
Solution and Explanation
Step 1: Recall the NO signaling pathway. Endothelial NO is a gas that crosses easily into nearby smooth muscle cells.
Step 2: Inside the cell, NO stimulates soluble guanylate cyclase to convert GTP into cyclic GMP, raising intracellular cGMP levels.
Step 3: Elevated cGMP behaves as a second messenger like cAMP, switching on protein kinases that relax the muscle and dilate the vessel.
Step 4: The other choices, the BRCA genes and interleukins, belong to DNA repair and immune signaling and have nothing to do with NO. Hence NO acts by increasing cGMP.
\[\boxed{\text{cGMP}}\]
Step 2: Inside the cell, NO stimulates soluble guanylate cyclase to convert GTP into cyclic GMP, raising intracellular cGMP levels.
Step 3: Elevated cGMP behaves as a second messenger like cAMP, switching on protein kinases that relax the muscle and dilate the vessel.
Step 4: The other choices, the BRCA genes and interleukins, belong to DNA repair and immune signaling and have nothing to do with NO. Hence NO acts by increasing cGMP.
\[\boxed{\text{cGMP}}\]
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