Question:medium
Muir-Torre syndrome shows:
Muir-Torre syndrome shows:
Show Hint
Look for the answer tied to sebaceous gland tumors plus internal cancers, not the NF1 or Ehlers-Danlos clues.
Updated On: Jun 24, 2026
- Sebaceous keratomas
- Lisch nodules
- Intestinal polyp
- Hyperelastic joints
Show Solution
The Correct Option is A
Solution and Explanation
Step 1: Anchor on what Muir-Torre syndrome actually is: a mismatch-repair-defect condition in the Lynch spectrum that pairs skin tumors with internal cancers.
Step 2: Its hallmark on the skin is a sebaceous gland tumor, ranging through sebaceous adenoma, epithelioma, and carcinoma, alongside keratoacanthomas. So the sebaceous keratoma option is the match.
Step 3: Eliminate by association. Lisch nodules are pathognomonic of neurofibromatosis type 1, intestinal polyps belong to hereditary polyposis syndromes, and hyperextensible joints are a clue to Ehlers-Danlos, none of which is Muir-Torre.
Step 4: The sebaceous skin tumor is therefore the distinguishing finding, and it should prompt a search for an underlying visceral malignancy.
\[\boxed{\text{Sebaceous keratomas}}\]
Step 2: Its hallmark on the skin is a sebaceous gland tumor, ranging through sebaceous adenoma, epithelioma, and carcinoma, alongside keratoacanthomas. So the sebaceous keratoma option is the match.
Step 3: Eliminate by association. Lisch nodules are pathognomonic of neurofibromatosis type 1, intestinal polyps belong to hereditary polyposis syndromes, and hyperextensible joints are a clue to Ehlers-Danlos, none of which is Muir-Torre.
Step 4: The sebaceous skin tumor is therefore the distinguishing finding, and it should prompt a search for an underlying visceral malignancy.
\[\boxed{\text{Sebaceous keratomas}}\]
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