Question:medium
MTP in 21-year-old, 10-week pregnancy is to be done by medical methods using
MTP in 21-year-old, 10-week pregnancy is to be done by medical methods using
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First-trimester (≤ 9–10 wk) medical abortion uses an antiprogesterone followed by a prostaglandin – think of the 'M + M' pair.
Updated On: Jun 22, 2026
- Intra uterine hyperosmotics
- Dinoprostone
- Oxytocin infusion
- M +M
Show Solution
The Correct Option is D
Solution and Explanation
Choose the drug by gestational age.
The deciding factor is that this is an EARLY (first-trimester, $10$-week) pregnancy needing a MEDICAL method. Each option is appropriate for a different gestational window, so match the regimen to $10$ weeks.
The correct early-medical-abortion regimen: The globally recommended first-trimester medical abortion (up to about $9$-$10$ weeks) is Mifepristone + Misoprostol (M + M). Mifepristone, an anti-progesterone, blocks progesterone support of the pregnancy and primes the cervix; misoprostol, a PGE$_1$ analogue taken $24$-$48$ h later, contracts the uterus and expels the products. This sequential combination gives the highest success rate for early termination and is the standard of care.
Why the alternatives fail at $10$ weeks:
- Intra-uterine hyperosmotic agents (hypertonic saline/urea instillation) are second-trimester methods, unsuitable and unsafe at $10$ weeks.
- Dinoprostone (PGE$_2$) is chiefly a cervical-ripening / second-trimester and labour-induction agent, not the first-line first-trimester abortifacient.
- Oxytocin infusion does not work in the first trimester because oxytocin receptors are sparse in the early uterus; it is reserved for term/intrapartum use.
So a $10$-week medical MTP is performed with mifepristone plus misoprostol.
Answer: D (M + M).
The deciding factor is that this is an EARLY (first-trimester, $10$-week) pregnancy needing a MEDICAL method. Each option is appropriate for a different gestational window, so match the regimen to $10$ weeks.
The correct early-medical-abortion regimen: The globally recommended first-trimester medical abortion (up to about $9$-$10$ weeks) is Mifepristone + Misoprostol (M + M). Mifepristone, an anti-progesterone, blocks progesterone support of the pregnancy and primes the cervix; misoprostol, a PGE$_1$ analogue taken $24$-$48$ h later, contracts the uterus and expels the products. This sequential combination gives the highest success rate for early termination and is the standard of care.
Why the alternatives fail at $10$ weeks:
- Intra-uterine hyperosmotic agents (hypertonic saline/urea instillation) are second-trimester methods, unsuitable and unsafe at $10$ weeks.
- Dinoprostone (PGE$_2$) is chiefly a cervical-ripening / second-trimester and labour-induction agent, not the first-line first-trimester abortifacient.
- Oxytocin infusion does not work in the first trimester because oxytocin receptors are sparse in the early uterus; it is reserved for term/intrapartum use.
So a $10$-week medical MTP is performed with mifepristone plus misoprostol.
Answer: D (M + M).
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