Step 1: Diffusion across the membrane depends on how well a solute dissolves in the fatty interior of the bilayer. The better the lipid solubility, the higher the permeability.
Step 2: Ions face a barrier because of their charge and hydration shell, so all of them cross slowly compared with gases. But among ions themselves there is a ranking.
Step 3: Chloride moves through the membrane more freely than the cations sodium and potassium. Sodium is actively excluded by the Na-K pump, and potassium sits between the two. Comparing the three, chloride shows the greatest passive movement.
Step 4: So the single ion that diffuses most across the membrane is chloride.
\[\boxed{\text{Cl}^-}\]