Question:medium
Most common cytochrome P-450 enzyme for drug metabolism detoxification reactions is?
Most common cytochrome P-450 enzyme for drug metabolism detoxification reactions is?
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This isoform metabolises nearly 50% of all drugs.
Updated On: Jun 24, 2026
- CYP 3A4
- CYP 1A2
- CYP 2A6
- CYP 2B6
Show Solution
The Correct Option is A
Solution and Explanation
Step 1: The P-450 superfamily is organised into families (letters) and subfamilies followed by individual enzyme numbers, reflecting how closely their protein sequences match.
Step 2: Among the many isoforms, just a handful drawn from three families handle the bulk of human drug biotransformation.
Step 3: The single most prolific isoform is CYP3A4 (together with 3A5), responsible for metabolising close to half of all drugs, which makes it the dominant detoxification enzyme.
Step 4: Compared with CYP1A2, 2A6 and 2B6, the 3A4 isoform processes a far greater share of the pharmacopoeia and is the one heavily affected by inducers like rifampin and phenytoin.
\[\boxed{\text{CYP 3A4}}\]
Step 2: Among the many isoforms, just a handful drawn from three families handle the bulk of human drug biotransformation.
Step 3: The single most prolific isoform is CYP3A4 (together with 3A5), responsible for metabolising close to half of all drugs, which makes it the dominant detoxification enzyme.
Step 4: Compared with CYP1A2, 2A6 and 2B6, the 3A4 isoform processes a far greater share of the pharmacopoeia and is the one heavily affected by inducers like rifampin and phenytoin.
\[\boxed{\text{CYP 3A4}}\]
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