Question:medium
Michaelis-Gutmann bodies are seen in which condition?
Michaelis-Gutmann bodies are seen in which condition?
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Laminated calcified bodies in defective bladder macrophages point to which lesion?
Updated On: Jun 24, 2026
- Xanthogranulomatous pyelonephritis
- Pyelonephritis
- Malakoplakia
- Nail patella syndrome
Show Solution
The Correct Option is C
Solution and Explanation
Step 1: Anchor on the buzzword. Targetoid, laminated, calcified inclusions known as Michaelis-Gutmann bodies are pathognomonic for one entity: malakoplakia.
Step 2: Understand the lesion. Malakoplakia is a defective-macrophage disorder seen mainly in the urinary bladder, driven by persistent coliform infection. The macrophages fail to fully digest bacteria, so undigested material accumulates and mineralises inside enlarged phagolysosomes.
Step 3: Those mineralised concretions are the Michaelis-Gutmann bodies. They take up calcium stains (von Kossa) and iron stains (Perls), are PAS positive and diastase resistant, and sit both inside and between the foamy von Hansemann macrophages, often immunopositive for CD68.
Step 4: Neither xanthogranulomatous pyelonephritis, ordinary pyelonephritis, nor nail-patella syndrome features these bodies, so the diagnosis is malakoplakia.
\[\boxed{\text{Malakoplakia}}\]
Step 2: Understand the lesion. Malakoplakia is a defective-macrophage disorder seen mainly in the urinary bladder, driven by persistent coliform infection. The macrophages fail to fully digest bacteria, so undigested material accumulates and mineralises inside enlarged phagolysosomes.
Step 3: Those mineralised concretions are the Michaelis-Gutmann bodies. They take up calcium stains (von Kossa) and iron stains (Perls), are PAS positive and diastase resistant, and sit both inside and between the foamy von Hansemann macrophages, often immunopositive for CD68.
Step 4: Neither xanthogranulomatous pyelonephritis, ordinary pyelonephritis, nor nail-patella syndrome features these bodies, so the diagnosis is malakoplakia.
\[\boxed{\text{Malakoplakia}}\]
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