Meigs Syndrome -- Complete OverviewClassical triad:- Benign ovarian tumor -- most commonly ovarian fibroma (also fibrothecoma, thecoma)
- Ascites
- Pleural effusion (right-sided in 70%, bilateral in 10%, left-sided in 10%)
Key feature: All three resolve completely after surgical excision of the ovarian fibroma. This distinguishes it from malignant etiologies of the same triad.
Pseudo-Meigs syndrome: Same triad but with non-fibroma pelvic masses (teratoma, Brenner tumor, uterine leiomyoma, struma ovarii).
Pathophysiology: Tumor produces peritoneal fluid (ascites) which crosses the diaphragm via lymphatics into the pleural space, preferentially on the right side due to diaphragmatic lymphatic anatomy.
Serum CA-125 may be elevated in Meigs syndrome (may mimic malignancy -- important clinical trap).
\[\boxed{\text{Meigs syndrome: Ovarian fibroma + Ascites + Pleural effusion}}\]