Question

Match the LIST-I with LIST-II 

Choose the correct answer from the options given below: 
 

• A. A-III, B-II, C-I, D-IV
• B. A-I, B-III, C-II, D-IV
• C. A-II, B-I, C-IV, D-III
• D. A-II, B-III, C-I, D-IV

Hint:

A mnemonic to remember the three major trisomies: at age {13} (Patau) you can go to a {P}G-13 movie, at age {18} (Edward's) you are an {E}ligible voter, and at age {21} (Down's) you can go {D}rinking.

Answer 1

The Correct Option is D

Step 1: Concept Explanation:
This question assesses understanding of aneuploidy, specifically trisomies. Trisomy is a genetic condition where an individual has three copies of a chromosome instead of the typical two. Each syndrome listed is linked to a particular chromosome.
Step 2: Detailed Solution:
Match each condition to its corresponding chromosomal abnormality:
- A. Edward's syndrome: A severe genetic disorder caused by an extra copy of chromosome 18, also known as Trisomy 18. Therefore, A corresponds to II.
- B. Down's syndrome: The most prevalent chromosomal disorder, resulting from a full or partial extra copy of chromosome 21, also known as Trisomy 21. Thus, B corresponds to III.
- D. Patau's syndrome: A syndrome resulting from extra genetic material from chromosome 13. Also known as Trisomy 13. Therefore, D corresponds to IV.
- C. Mosaic trisomy: Mosaicism involves a mix of cells, some with the standard number of chromosomes and others with an extra chromosome. While mosaicism can occur with any trisomy, Trisomy 16 is most frequently observed in pregnancies, usually leading to miscarriage in full trisomy cases. Live births are possible with mosaic Trisomy 16. Given the other matches, pairing Mosaic trisomy with Trisomy of 16 is logical. Thus, C corresponds to I.
Step 3: Final Answer:
Combining the matches:
A $\rightarrow$ II (Trisomy of 18)
B $\rightarrow$ III (Trisomy of 21)
C $\rightarrow$ I (Trisomy of 16)
D $\rightarrow$ IV (Trisomy of 13)
The correct combination is A-II, B-III, C-I, D-IV, corresponding to option (D).