Question

Match the following drugs and their Mechanism of Action (MOA):

• A. (1)-(R), (2)-(S), (3)-(P), (4)-(Q)
• B. (1)-(Q), (2)-(S), (3)-(P), (4)-(R)
• C. (1)-(R), (2)-(Q), (3)-(P), (4)-(S)
• D. (1)-(Q), (2)-(R), (3)-(S), (4)-(P)

Hint:

Understanding drug mechanisms is vital for rational therapy and predicting adverse effects or resistance mechanisms in tuberculosis treatment.

Answer 1

The Correct Option is A

Four anti-tubercular drugs need to be matched to their molecular targets. Taking each drug on its own confirms which target it belongs to.

1. Ethambutol: Stops arabinosyl transferase from building the arabinogalactan layer of the mycobacterial cell wall, matching it to target R.
2. Para-aminosalicylic acid: Acts as a false substrate for folate synthase, blocking folate production the bacteria need to grow, matching it to target S.
3. Rifampicin: Binds bacterial DNA-dependent RNA polymerase and blocks transcription, matching it to target P.
4. Bedaquiline: Blocks mycobacterial ATP synthase, cutting off the organism's main energy production pathway, matching it to target Q.

Putting these four matches together gives (1)-(R), (2)-(S), (3)-(P), (4)-(Q).

So the correct answer is (1)-(R), (2)-(S), (3)-(P), (4)-(Q).