Question

Match the following Class and their Antiarrhythmic Drug:

• A. (1)-(P), (2)-(Q), (3)-(R), (4)-(S)
• B. (1)-(Q), (2)-(R), (3)-(S), (4)-(P)
• C. (1)-(R), (2)-(Q), (3)-(P), (4)-(S)
• D. (1)-(Q), (2)-(R), (3)-(P), (4)-(S)

Hint:

The Vaughan Williams classification helps in identifying antiarrhythmic agents by their primary mechanism and is essential in managing arrhythmias effectively.

Answer 1

The Correct Option is A

Step 1: Understanding the Concept:
The Vaughan Williams system groups antiarrhythmic drugs into four classes by the ion channel or receptor they act on, and each class has one representative drug you need to know by name.

Step 2: Key Formula or Approach:
Go class by class and recall one prototype drug for each: Class I blocks sodium channels, Class II blocks beta receptors, Class III blocks potassium channels, and Class IV blocks calcium channels.

Step 3: Detailed Explanation:
Class I, sodium channel blockade, is represented by Disopyramide, so (1) pairs with (P).
Class II, beta blockade, is represented by Metoprolol, so (2) pairs with (Q).
Class III, potassium channel blockade, is represented by Amiodarone, so (3) pairs with (R).
Class IV, calcium channel blockade, is represented by Verapamil, so (4) pairs with (S).
Putting these four pairs together gives (1)-(P), (2)-(Q), (3)-(R), (4)-(S).

Step 4: Final Answer:
The correct match is (1)-(P), (2)-(Q), (3)-(R), (4)-(S).