Question

Match LIST-I with LIST-II 

Choose the correct answer from the options given below: 
 

• A. A-I, B-II, C-III, D-IV
• B. A-I, B-III, C-II, D-IV
• C. A-II, B-I, C-IV, D-III
• D. A-II, B-III, C-IV, D-I

Hint:

To remember inheritance patterns, link diseases to key concepts. {Dominant} means one copy of the gene is enough (Huntington's). {Recessive} means two copies are needed (Cystic Fibrosis). {X-linked} affects males more often (Color blindness).

Answer 1

The Correct Option is D

Step 1: Concept Overview:
This question tests your understanding of common genetic disease inheritance patterns: autosomal dominant, autosomal recessive, X-linked dominant, and X-linked recessive. These patterns dictate how traits are passed down through generations.
Step 2: Detailed Explanation:
Let's match each disease with its inheritance pattern:
- A. Cystic fibrosis: Affects mucus and sweat glands. Inheritance: autosomal recessive (requires two copies of the mutated gene). Therefore, A matches with II.
- B. Fragile X Syndrome: The most common inherited cause of intellectual disability. Inheritance: X-linked dominant. Its X-linked nature results in differing inheritance between sexes. Therefore, B matches with III.
- C. Huntington's disease: A progressive neurodegenerative disorder. Inheritance: autosomal dominant (requires only one copy of the mutated gene). Therefore, C matches with IV.
- D. Color blindness: Red-green color blindness is inherited in an X-linked recessive pattern. More prevalent in males (due to having only one X chromosome). Therefore, D matches with I.
Step 3: Solution:
The matches are as follows:
A $\rightarrow$ II (Autosomal recessive)
B $\rightarrow$ III (X-linked dominant)
C $\rightarrow$ IV (Autosomal dominant)
D $\rightarrow$ I (X-linked recessive)
The correct answer is A-II, B-III, C-IV, D-I, which is option (D).