Question

Match List I with List II :

List I                  List II
A. Tetany               I. Inflammation of joints
B. Arthritis            II. Autoimmune disorder affecting neuromuscular junction
C. Myasthenia gravis    III. Wild contraction in muscle due to low Ca++ in body fluid
D. Muscular dystrophy   IV. Progressive degeneration of skeletal muscle

• A. A-IV, B-III, C-II, D-I
• B. A-III, B-I, C-II, D-IV
• C. A-I, B-II, C-III, D-IV
• D. A-III, B-II, C-I, D-IV

Hint:

Logic Tip: Pay attention to keywords. "Myasthenia" means muscle weakness, linked to the "Neuromuscular junction". "Dystrophy" indicates a genetic "Degeneration". "Tetany" sounds like tetanus, involving "Wild contractions".

Answer 1

The Correct Option is B

Step 1 : Understanding the Question:
The goal is to correctly match specific medical disorders of the human muscular and skeletal systems with their primary pathological descriptions or physiological causes. This includes genetic, inflammatory, autoimmune, and metabolic conditions.
Step 2 : Key Formulas and Approach:
The approach involves identifying the specific "keyword" associated with each disorder:
1. Tetany: Associated with low Calcium and Spasms.
2. Arthritis: Associated with Joint Inflammation.
3. Myasthenia: Associated with Autoimmune attacks on the Nerve-Muscle junction.
4. Dystrophy: Associated with Genetic Progressive Degeneration.
Step 3 : Detailed Explanation:

Tetany (A): This condition is characterized by rapid, uncontrollable wild contractions (spasms) in the skeletal muscles. It is biochemically caused by hypocalcemia, which is a critically low concentration of Calcium ($Ca^{++}$) in the body fluids. (Match: A-III).

Arthritis (B): This is a common musculoskeletal condition specifically defined as the inflammation of joints. It results in pain, stiffness, and reduced mobility in the affected joints. (Match: B-I).

Myasthenia gravis (C): This is a chronic autoimmune disorder. In this condition, the immune system mistakenly attacks the acetylcholine receptors at the neuromuscular junction, leading to progressive muscle fatigue and weakness. (Match: C-II).

Muscular dystrophy (D): This refers to a group of genetic disorders characterized by the progressive degeneration of skeletal muscle over time, usually due to the absence of the protein dystrophin. (Match: D-IV).

Step 4 : Final Answer:
Matching the disorders to their corresponding descriptions gives the sequence: A-III, B-I, C-II, and D-IV. This alignment is provided in option (B).