Question

Marked bleeding is seen in which of following conditions ?

• A. VMA disease
• B. Haemophilia A
• C. Haemophilia B
• D. ALL

Answer 1

The Correct Option is D

Step 1: Compare the bleeding mechanisms. Hemophilias and von Willebrand disease impair coagulation factors or platelet adhesion in a defined, usually graded manner.

Step 2: In acute lymphoblastic leukemia, malignant lymphoblasts crowd out the bone marrow, sharply reducing platelet production. Severe thrombocytopenia is a hallmark and drives heavy spontaneous bleeding.

Step 3: While von Willebrand disease is the most common inherited bleeding disorder and the hemophilias cause joint and soft-tissue bleeds, the marrow failure of ALL can produce the most striking, widespread hemorrhage among these options.

Step 4: Hence the recall key marks ALL as the condition with marked bleeding.

\[\boxed{\text{ALL}}\]