Question:medium
Liver biopsy is indicated in all of the following except:
Liver biopsy is indicated in all of the following except:
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Biopsy is avoided in amoebic liver disease due to risk of rupture and bleeding.
Updated On: Jun 24, 2026
- Amoebic hepatitis
- Wilson's disease
- Chronic hepatitis B and C
- Autoimmune hepatitis
Show Solution
The Correct Option is A
Solution and Explanation
Step 1: The question lists conditions and asks which one does not call for a liver biopsy. Reviewing each helps isolate the odd one out.
Step 2: Three of the options rely on biopsy. Chronic viral hepatitis B and C need tissue to grade inflammation and stage fibrosis, Wilson's disease needs hepatic copper measured on the sample, and autoimmune hepatitis is confirmed and monitored histologically.
Step 3: Amoebic involvement of the liver breaks this pattern. The lesion is typically a pus-filled abscess, and pushing a needle into it can trigger haemorrhage or rupture and spread infection. It is diagnosed with imaging and amoebic serology, then treated with metronidazole.
Step 4: Because biopsy is avoided rather than recommended here, amoebic hepatitis is the exception.
\[\boxed{\text{Amoebic hepatitis}}\]
Step 2: Three of the options rely on biopsy. Chronic viral hepatitis B and C need tissue to grade inflammation and stage fibrosis, Wilson's disease needs hepatic copper measured on the sample, and autoimmune hepatitis is confirmed and monitored histologically.
Step 3: Amoebic involvement of the liver breaks this pattern. The lesion is typically a pus-filled abscess, and pushing a needle into it can trigger haemorrhage or rupture and spread infection. It is diagnosed with imaging and amoebic serology, then treated with metronidazole.
Step 4: Because biopsy is avoided rather than recommended here, amoebic hepatitis is the exception.
\[\boxed{\text{Amoebic hepatitis}}\]
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