Step 1: The problem requires finding the limit of an integral expression.
Step 2: The integral is:
\[ \int_4^{f(x)} \frac{2t}{x-1} \, dt \]
Given \( f(x) \) is differentiable and \( f(1) = 4 \), we can use the Fundamental Theorem of Calculus.
Step 3: The integral remains:
\[ \int_4^{f(x)} \frac{2t}{x-1} \, dt \]
As \( x \to 1 \), \( f(x) \to 4 \). We analyze the integral's behavior as \( x \) approaches 1.
Step 4: The integrand \( \frac{2t}{x-1} \) suggests the integral is proportional to \( \frac{1}{x-1} \).
Step 5: Differentiating the integral with respect to \( x \):
\[ \frac{d}{dx} \left( \int_4^{f(x)} \frac{2t}{x-1} \, dt \right) = \frac{2f(x)}{x-1} \cdot f'(x) \]
Step 6: Substituting \( f(1) = 4 \) and \( f'(1) = 2 \), evaluate the limit at \( x = 1 \):
\[ \lim_{x \to 1} \frac{2f(x)}{x-1} \cdot f'(x) = 16 \]
Therefore, the expression's value is \( \boxed{16} \).