Question:easy
Leiden thrombophilia is caused by a mutational abnormality of which of the following factors?
Leiden thrombophilia is caused by a mutational abnormality of which of the following factors?
Show Hint
The condition's own name reveals the clotting factor.
Updated On: Jun 24, 2026
- Factor V
- Factor VII
- Factor IX
- Factor X
Show Solution
The Correct Option is A
Solution and Explanation
Step 1: Decode the name. The disorder is literally called Factor V Leiden thrombophilia, naming both the factor involved and the city where it was described, and it is the commonest inherited clotting tendency.
Step 2: State the genetic defect. It results from a single mutation in the $Factor\ V$ gene that alters the protein.
Step 3: Trace the consequence. The altered Factor V cannot be cleaved and inactivated by activated protein C, removing a natural brake on coagulation and leaving the patient prone to abnormal venous clots.
Step 4: Rule out the rest. None of Factor VII, IX, or X is implicated in this entity, so the answer must be Factor V.
\[\boxed{\text{Factor V}}\]
Step 2: State the genetic defect. It results from a single mutation in the $Factor\ V$ gene that alters the protein.
Step 3: Trace the consequence. The altered Factor V cannot be cleaved and inactivated by activated protein C, removing a natural brake on coagulation and leaving the patient prone to abnormal venous clots.
Step 4: Rule out the rest. None of Factor VII, IX, or X is implicated in this entity, so the answer must be Factor V.
\[\boxed{\text{Factor V}}\]
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