Question

LCAT deficiency increases which of the following?

• A. HDL
• B. LDL
• C. VLDL
• D. Chylomicron

Hint:

LCAT matures this lipoprotein by esterifying its free cholesterol.

Answer 1

The Correct Option is A

Step 1: The enzyme LCAT works specifically on the surface of HDL particles. It takes free cholesterol and adds a fatty acid to lock it into the particle core as cholesterol ester.
Step 2: Losing LCAT means free cholesterol cannot be esterified, so HDL stays in its flat, immature nascent shape and fails to fill out into mature spherical HDL.
Step 3: Because the disorder is defined by abnormal, unmatured HDL carrying excess free cholesterol, HDL is the lipoprotein flagged in this question. The other lipoproteins - LDL, VLDL, chylomicron - are not the primary LCAT substrate.\[\boxed{HDL}\]