Question:medium

Lamotrigine is a broad-spectrum antiepileptic. For which of the following seizure types is lamotrigine particularly useful and a recognised first/adjunctive choice?

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Broad-spectrum Na-channel blocker; can aggravate myoclonus, but good for GTCS.
Updated On: Jun 25, 2026
  • Generalised tonic-clonic seizures (GTCS)
  • Myoclonic seizures
  • Absence seizures
  • Atonic seizures
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The Correct Option is A

Solution and Explanation

Lamotrigine stabilises neuronal membranes by use-dependent blockade of voltage-gated $Na^+$ channels, damping repetitive firing and presynaptic glutamate release. This pharmacology makes it strong against partial (focal) seizures and secondarily generalised / primary generalised tonic-clonic seizures.

Cross-checking the options: myoclonic jerks may be provoked by lamotrigine, absence seizures respond better to ethosuximide and valproate, and atonic drops belong to Lennox-Gastaut management where lamotrigine is adjunctive only. The cleanest, board-favoured indication among the four is generalised tonic-clonic seizures.
\[\boxed{\text{Lamotrigine is particularly useful for GTCS}}\]
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