Question:medium

Interaction of Methotrexate with sulfonamides (such as Sulfamethoxazole and Sulfisoxazole) may lead to which type of drug interaction

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Sulfonamides are "bullies" on albumin—they displace Methotrexate and Warfarin.
Updated On: May 25, 2026
  • Reduced absorption of methotrexate
  • Methotrexate direct folate antagonist
  • Displacement of methotrexate from plasma protein-binding sites
  • Increased renal excretion of methotrexate
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The Correct Option is C

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