Question

In which of these conditions may CPK be raised?

• A. Muscle disease
• B. Liver cirrhosis
• C. Biliary colic
• D. Amyotrophic lateral sclerosis

Hint:

CPK sits inside muscle cells; think about which option actually damages muscle fibers.

Answer 1

The Correct Option is A

CPK leaks into blood only when the cells that hold it, mainly muscle cells, get damaged. Let's check each option against that rule.

1. Muscle disease: Directly injures muscle fibers, so CPK spills into the blood and the level rises. This fits.
2. Liver cirrhosis: Damages liver cells, which raises liver enzymes and bilirubin, not CPK.
3. Biliary colic: A blocked bile duct raises ALP and bilirubin, again with no muscle injury involved.
4. Amyotrophic lateral sclerosis: Attacks the nerve cells controlling muscle, not the muscle fibers themselves, so CPK is usually normal or only slightly high.

Only muscle disease causes true muscle breakdown, so it is the condition where CPK is clearly raised.

Let's summarize:

• CPK is a muscle enzyme, so it rises with muscle cell damage.
• Liver and biliary problems raise a different set of enzymes altogether.
• Nerve-cell diseases like ALS spare the muscle fiber itself, so CPK stays close to normal.

The condition with a raised CPK is muscle disease.