Step 1: Reason with the direction of increase:
$Z = 3x + 5y$ increases as x and y increase. So the smallest value is at the corner nearest the origin and the largest at a corner far from it.
Step 2: Extremes:
The smallest Z is at the corner nearest the origin, $(5, 5)$, with $Z = 40$. The largest is at the farthest corner on the line $x + 3y = 60$ with larger x, which is $(15, 15)$, $Z = 120$, compared with 100 at $(0, 20)$. Difference $120 - 40 = 80$ (D).
Final Answer:
80.
\[ \boxed{80} \]