Question:medium

In Michaelis-Menten equation when Km=C:

Updated On: Jul 14, 2026
  • The rate of process is equal to half of maximum rate
  • Indicates zero-order process
  • The rate process occurs at a constant rate
  • Equation becomes identical to first order elimination of drug
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The Correct Option is A

Solution and Explanation

Step 1: Understanding the Concept:
This question tests what the Michaelis-Menten equation predicts at one specific condition, when the concentration C is set equal to the Michaelis constant Km.

Step 2: Key Concept or Approach:
Start from the standard form of the equation, \( v = \dfrac{V_{max} \cdot C}{K_m + C} \), and substitute \( C = K_m \) directly to see what the rate simplifies to.

Step 3: Detailed Explanation:
Substituting \( C = K_m \) gives \( v = \dfrac{V_{max} \cdot K_m}{K_m + K_m} = \dfrac{V_{max} \cdot K_m}{2K_m} \).
The \( K_m \) terms cancel, leaving \( v = \dfrac{V_{max}}{2} \).
This is different from zero-order behavior, which needs C much larger than Km so that v stays close to Vmax regardless of concentration.
It is also different from first-order behavior, which needs C much smaller than Km so that v becomes roughly proportional to C.
Neither of those approximations applies when C is set exactly equal to Km, so the only correct simplification is \( v = V_{max}/2 \).

Step 4: Final Answer:
When Km equals C, the rate of the process equals half of the maximum rate.
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