Question:medium
In Bartter syndrome, the defect is seen in:
In Bartter syndrome, the defect is seen in:
Show Hint
It behaves like a permanent loop diuretic; think where they act.
Updated On: Jun 24, 2026
- Defect in PCT
- Defect in DCT
- Defect in thick ascending limb of loop of Henle
- None
Show Solution
The Correct Option is C
Solution and Explanation
Step 1: Picture Bartter syndrome as a built-in loop diuretic, then locate where loop diuretics act.
Step 2: Loop diuretics block the Na-K-2Cl cotransporter in the thick ascending limb, and Bartter syndrome is caused by inherited loss of function of that same transporter or the associated potassium and chloride channels. The result is salt wasting and an inability to concentrate the urine.
Step 3: A DCT defect points instead to Gitelman syndrome, and the PCT is the wrong site, so the lesion in Bartter syndrome is in the thick ascending limb of the loop of Henle.
\[\boxed{\text{Defect in thick ascending limb of loop of Henle}}\]
Step 2: Loop diuretics block the Na-K-2Cl cotransporter in the thick ascending limb, and Bartter syndrome is caused by inherited loss of function of that same transporter or the associated potassium and chloride channels. The result is salt wasting and an inability to concentrate the urine.
Step 3: A DCT defect points instead to Gitelman syndrome, and the PCT is the wrong site, so the lesion in Bartter syndrome is in the thick ascending limb of the loop of Henle.
\[\boxed{\text{Defect in thick ascending limb of loop of Henle}}\]
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