Question

In a patient with lipoprotein lipase deficiency, which of the following is increased following a fatty meal?

• A. Chylomicron
• B. LDL
• C. HDL
• D. Apo-A

Answer 1

The Correct Option is A

Step 1: Trace the fate of fat from a meal. Dietary triglycerides are packaged into chylomicrons in the gut, and LPL on the capillary endothelium normally breaks them down. Step 2: When LPL is deficient, this breakdown stalls, so the triglyceride-laden chylomicrons pile up in plasma, especially right after a fatty meal, giving a creamy supernatant and very high triglycerides. Step 3: Since chylomicrons and VLDL are not processed, the particles derived from them, namely LDL and HDL (with its Apo-A), remain low rather than elevated. Step 4: Among the options, only chylomicron rises after the fatty meal. \[\boxed{\text{Chylomicron}}\]