Question

In a drug discovery process:
1. Lead optimization
2. Target selection
3. Lead findings

• A. 3-2-1
• B. 1-2-3
• C. 2-3-1
• D. 3-1-2

Hint:

In drug discovery: Identify the target (2), find a lead compound (3), and optimize it (1) for better activity and safety.

Answer 1

The Correct Option is C

Step 1: Understanding the Concept:
We are given three stages of drug discovery, lead optimization, target selection, and lead finding, and need to work out the order in which they happen.

Step 2: Key Formula or Approach:
A drug cannot be found or improved without first knowing what biological molecule it needs to act on, so the process must always begin with choosing that target.

Step 3: Detailed Explanation:
The first stage has to be target selection, where a protein or other biomolecule tied to the disease is picked and confirmed as a valid drug target.
Once the target is fixed, chemical libraries or natural extracts are screened against it, and any compound that shows activity becomes a lead, which is the lead finding stage.
With one or more leads in hand, chemists then adjust the structure step by step to boost potency, improve selectivity for the target, and reduce side effects, which is lead optimization.
Writing this out with the question's numbering, target selection is step 2, lead finding is step 3, and lead optimization is step 1, giving the sequence 2, 3, 1.

Step 4: Final Answer:
The correct order is 2-3-1.