Question:medium

In a DNA molecule, which of the following base-pairings is correct?

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Remember the base pairing rules: In DNA, A pairs with T and G pairs with C. This is known as complementary base pairing and is fundamental to the structure of the DNA molecule.
Updated On: Nov 26, 2025
  • Adenine pairs with Cytosine.
  • Thymine pairs with Guanine.
  • Adenine pairs with Thymine.
  • Cytosine pairs with Uracil.
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The Correct Option is C

Solution and Explanation

Hydrogen bonds between nitrogenous bases dictate base-pairing rules in the DNA double helix. The valid base pairings in DNA are:

  • Adenine (A) forms two hydrogen bonds with Thymine (T).
  • Guanine (G) forms three hydrogen bonds with Cytosine (C).

Therefore, the correct base pairings are: Adenine with Thymine, and Guanine with Cytosine.

The invalid options are:

  • Option (1): Adenine does not pair with Cytosine; it pairs with Thymine.
  • Option (2): Thymine does not pair with Guanine; it pairs with Adenine.
  • Option (4): Cytosine does not pair with Uracil. Cytosine pairs with Guanine in DNA. Uracil is present in RNA and pairs with Adenine.

Consequently, the correct selection is Option (3).

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