Hershey and Chase determined that DNA, to the exclusion of protein, is the genetic substance controlling inheritance. \begin{itemize} \item Observation: $^{32}$P (incorporated into DNA) penetrated bacterial cells during phage infection, whereas $^{35}$S (incorporated into protein) stayed external. \item Impact: This conclusion redirected molecular biology research towards understanding DNA's structure and its hereditary function, facilitating subsequent major breakthroughs such as the elucidation of the double-helix model.\end{itemize}% Quick tip