Question

(iii) Work out a cross to explain how normal parents may have a sicklecell anaemic child.

Hint:

A Punnett square can effectively illustrate inheritance patterns of sicklecell anaemia and other genetic disorders.

Answer 1

If both parents are carriers of the sickle cell trait (HbA HbS), there is a 25% probability that their offspring will inherit two sickle cell alleles (HbS HbS), resulting in the disorder.