Step 1: Go back to the definition of variance.
$\operatorname{Var}(Y)=E\big[(Y-E(Y))^2\big]$. With $Y=4X+2$, we have $E(Y)=4E(X)+2$, so $Y-E(Y)=4X+2-(4E(X)+2)=4\big(X-E(X)\big)$.
Step 2: Square this difference.
$(Y-E(Y))^2=16\big(X-E(X)\big)^2$, and taking expectation on both sides gives $\operatorname{Var}(Y)=16\operatorname{Var}(X)$.
Step 3: Plug in the given variance.
$\operatorname{Var}(X)=4$, so $\operatorname{Var}(Y)=16\times4=64$.
\[ \boxed{64} \]