If the DRT for C.botulinum at $121^\circ C$ is 0.25, then for 12 D process, the time required for heating at $121^\circ C$ is .........minute.
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The "Botulinum Cook" is always $F_0 = 3$ min. This is a foundational constant in thermal processing. If you see $D = 0.25$ and $12D$, the answer is always $3$.