If $A(2, 4)$ and $B(6, 10)$ are two fixed points and if a point $P$ moves so that $\angle APB$ is always a right angle, then the locus of $P$ is:
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Alternatively, you can use the slope condition: $m_{AP} \times m_{BP} = -1$. This results in $\frac{y-4}{x-2} \times \frac{y-10}{x-6} = -1$, which leads to the same diameter form equation.