Step 1: Look for the extreme word.
Statement D says optimal stress always improves immunity. Such absolute words are usually a sign of a wrong statement.
Step 2: Test A, B and C with facts.
Chronic stress is linked with more infections and slower healing, which supports A. Lower natural killer cell activity is a well known finding under stress, which supports B. High cortisol and other stress hormones dampen immune response and harm health, which supports C.
Step 3: Decide on D.
Short bursts of mild stress can raise some immune activity, but it is not true in every case, so the word always makes D incorrect.
Step 4: Use the option pattern.
Options (1), (3) and (4) each contain D. As D is false, they cannot be right.
Step 5: Select.
Only option (2), A, B and C only, is left.
Final Answer:
A, B and C are true and D is false, so option (2).