Comprehension
I am the family face; flesh perishes. I live on, projecting trait and trace through time to times anon, and leaping from place to place over oblivion.
So wrote Thomas Hardy in his poem, Heredity, describing direct descent of life from one generation to the next. Indeed, the poem reflects the DNA in our genome. Dr.Drew Endy of MIT quoted this when he described how people at the J. Craig Venter Institute (JCVI) bypass nature’s constraint of direct descent. Scientists there have used chemistry and biochemistry to produce the first synthetic genome in the laboratory. They chemically synthesized many fragments of the DNA, encoding the 582,970-units-long genome of a bacterium called Mycoplasma genitalium. Next, they assembled these fragments in perfect order to generate the genome of the bacterium.
The DNA sequence of the synthetic one was confirmed to be identical to the natural one. While the DNA pieces were synthesized chemically, the stitching together was done using the biochemical machinery of a host cell. About 100 pieces of the genome, each 5000-7000 units long in DNA sequence, were first joined to produce 25 sub-assemblies, each about 24000 base pairs long. These were then introduced into the bacterium E. coli to produce sufficient DNA for the next steps. Next, they repeated the procedure to generate large fragments comprising l/4th of the whole genome of M.genitalium.
Now, they used the clever trick of exploiting the process called homologous recombination. This is a basic essential process in every cell, which physically rearranges the two strands of DN The JCVI researchers inserted the synthesized DNA fragments into yeast and utilized its homologous recombination ability to generate the whole 580,000 long genome of M.genitalium in one step. 
This is clearly a landmark work that leads into the brave new world of synthesizing life itself in the laboratory. It was hardly 200 years ago when Friedrich Wohler synthesized urea, an organic molecule, in the chemical laboratory, thus throwing out the notion of ‘vital forces’ involved in the components of living organisms. What is the next step, making life itself in the lab, bypassing nature? With single cell organisms like M.genitalium, it might not be far away. It is now possible in the lab to do so, by inserting the genome into a ‘host’ cell and asking the latter to make the bacterium of your choice. If only we find a way to insert the bacterial genome into this proto-cell, and somehow trigger it to make the bacterium itself! We would have chemically created life in the la This is not a pipedream; JCVI scientists are already on the job, and my bet is they will do it within a few years. 
This surely raises ethical questions, a matter that JCVI is keenly aware of and is already engaged in with ethicists. Even their present work on M.genitalium was done with prior approval of ethical experts. But then, today it is M.genitalium, tomorrow it could be a more advanced, multi-cellular organism, and that could flummox even the ethicist. Assisted reproduction, which is the other side of the coin and truly a recently initiated technology, has become ethically and morally acceptable. Cloning of Dolly, the sheep, has not raised any outrage, but cloning a human certainly does.
Question: 1

Why does the author refer to Thomas Hardy’s poem?

Updated On: Jan 13, 2026
  • To estimate the role played by direct properties attributable to one’s parentage
  • To underline the significance of the biological process whereby genetic factors are transmitted from one generation to the next
  • To emphasize the importance of the total of inherited attributes that rarely come by natural descent
  • To highlight the purpose of genetic endowment which can traced through the family face
  • To evaluate the function of genes that are seldom present among the descendants of one individual
Show Solution

The Correct Option is B

Solution and Explanation

The correct answer is option (B):
To underline the significance of the biological process whereby genetic factors are transmitted from one generation to the next

The correct answer is "To underline the significance of the biological process whereby genetic factors are transmitted from one generation to the next".

The question asks *why* the author mentions Thomas Hardy's poem. The purpose of referencing an external work like a poem is usually to illustrate, support, or expand upon a point being made by the author. In the context of genetics and inheritance, a poem that likely discusses familial traits or resemblances would be used to highlight the process of how genetic information moves from parents to offspring. The other options are incorrect because they focus on aspects that are not the primary focus of inheritance. For instance, estimating the *role* of properties or emphasizing *importance* of the total of inherited attributes are related, but less specific to the core biological process itself. Highlighting the *purpose* or evaluating the *function* of genes are similar, but lack the direct reference to the generational transmission. The poem likely portrays how traits are passed down, making the correct answer the one that most closely describes that fundamental concept.
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Question: 2

What did the scientists at JCVI do?

Updated On: Jan 13, 2026
  • They circumvented nature’s constraint of direct descent
  • They bypassed nature’s laws and produced a natural gene
  • They invented an imperishable gene which is synthetic in nature
  • They ignored the theory of inheritance and created an intrinsic gene
  • They produced a gene which can be preserved permanently
Show Solution

The Correct Option is A

Solution and Explanation

The correct answer is option (A):
They circumvented nature’s constraint of direct descent

The correct answer, "They circumvented nature's constraint of direct descent," best describes the work of scientists at the J. Craig Venter Institute (JCVI). The term "circumvented" means to overcome or bypass a restriction. In this context, it refers to the scientists' ability to create synthetic life. Nature's constraint of direct descent refers to the usual process of inheritance where offspring inherit genes from their parents. By creating a synthetic genome and inserting it into a cell, JCVI scientists essentially bypassed the need for this direct descent, creating a new life form from scratch.

Let's look at why the other options are incorrect:

* "They bypassed nature’s laws and produced a natural gene": While they worked with natural genetic code, the gene they created was synthetic, not naturally occurring in the traditional sense. Furthermore, scientists do not necessarily bypass "laws" of nature, but use the understanding of those laws to achieve a desired outcome.
* "They invented an imperishable gene which is synthetic in nature": The term "imperishable" is not accurate. While the synthetic gene they created may be durable, it is not inherently designed to be indestructible or live forever.
* "They ignored the theory of inheritance and created an intrinsic gene": The scientists did not ignore the theory of inheritance; they understood it very well. Their work built upon and expanded our understanding of genetics and inheritance. The term "intrinsic gene" is not a standard scientific term to describe their accomplishment.
* "They produced a gene which can be preserved permanently": The ability to preserve the gene is not the primary achievement. The key breakthrough was the creation of a fully synthetic genome.
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Question: 3

What was the outcome of their research?

Updated On: Jan 13, 2026
  • They analyzed the DNA sequence of the synthetic gene in the laboratory for the first time
  • They contrasted the properties of a synthetic gene with that of a natural one
  • They created a gene sequence in artificial conditions which could undergo mutation
  • They produced the first synthetic genome in the laboratory which is analogous to the natural one
  • They studied the functions of a natural gene and a synthetic gene under controlled conditions of a laboratory
Show Solution

The Correct Option is D

Solution and Explanation

The correct answer is option (D):
They produced the first synthetic genome in the laboratory which is analogous to the natural one

The correct answer is "They produced the first synthetic genome in the laboratory which is analogous to the natural one." This is the only option that directly describes a significant and groundbreaking scientific achievement: the creation of a complete, artificial genome. The other options describe related but less impactful steps in genetic research. Analyzing DNA sequences, comparing properties of genes, or studying their functions are important parts of the research process, but they do not represent the culmination of the work, which would be the successful synthesis of an entire genome. The phrase "analogous to the natural one" highlights the key aspect of this breakthrough – that the synthetic genome functioned in a way that mimicked its natural counterpart, indicating a successful replication of the core components of life.
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Question: 4

The DNA pieces of the synthetic genome were stitched together by using

Updated On: Jan 13, 2026
  • The method of biochemical synthesis
  • The biochemical machinery of a host cell
  • The biochemical genome of a host cell
  • The DNA sequence of a host cell
  • The synthesized DNA pieces of a host cell
Show Solution

The Correct Option is B

Solution and Explanation

The correct answer is option (B):
The biochemical machinery of a host cell

The correct answer is "The biochemical machinery of a host cell". Here's why:

When assembling a synthetic genome, scientists don't typically just mix the DNA pieces together in a test tube and expect them to magically join. Instead, they leverage the natural processes found within living cells.

These cells, the "host cells", possess all the necessary tools – the "biochemical machinery" – to facilitate this complex assembly process. This machinery includes enzymes like ligases, which act like molecular glue to join DNA fragments together, as well as replication and repair mechanisms that ensure the newly constructed genome is stable and functional. The host cell provides the environment and the working tools to stitch the pieces of DNA together.

Let's look at why the other options are incorrect:

* "The method of biochemical synthesis": While the individual DNA pieces might be created using biochemical synthesis techniques, the act of putting them together into a complete genome relies on cellular machinery.
* "The biochemical genome of a host cell": The host cell's existing genome doesn't directly perform the assembly. It is the cellular machinery, not the existing genome sequence itself, that facilitates the process.
* "The DNA sequence of a host cell": The host cell's DNA sequence is useful for providing an environment but doesn't perform the action of stitching.
* "The synthesized DNA pieces of a host cell": The host cell utilizes its inherent processes.
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Question: 5

What is the author’s gut feeling?

Updated On: Jan 13, 2026
  • Scientists will invent a mechanism that might trigger a genome and convert it into the bacterium
  • Scientists will succeed in creating a synthetic genome which has the characteristics of a natural one
  • Scientists will improve upon the synthetic gene and find an alternative which is akin to the proto-cell of the bacterium
  • Scientists will prove that the DNA structure of a proto-cell is similar to that of an artificial one
  • Scientists will find a way to insert the bacterial genome into the proto-cell and somehow trigger it to make the bacterium itself
Show Solution

The Correct Option is

Solution and Explanation

The correct answer is option (E):
Scientists will find a way to insert the bacterial genome into the proto-cell and somehow trigger it to make the bacterium itself

The author's "gut feeling," in the context of scientific writing, refers to their intuitive prediction or expectation about the outcome of a scientific endeavor, even if it's not explicitly stated as a definitive conclusion. Analyzing the given options, the correct answer, "Scientists will find a way to insert the bacterial genome into the proto-cell and somehow trigger it to make the bacterium itself," represents the most complete and likely end-goal of the research being discussed.

Here's why:

* Focus on the Core Challenge: The central aim of synthetic biology in this context is to synthesize a functional, self-replicating bacterium. The correct answer highlights the necessary steps: (1) inserting the genetic blueprint (genome) into a (2) synthetic 'proto-cell' or cell-like structure and then (3) triggering this system to function and create the bacterium. This encapsulates the problem being solved.
* Logical Progression: This answer includes the progression of the experiments and the intended result, which makes it more likely.
* Alignment with Synthetic Biology Goals: This aligns with the overall goals of synthetic biology: to create life from scratch, or, more specifically, to build a functional, self-replicating cell. The other options might be intermediate steps or partial goals, but this represents the ultimate goal.
* Comprehensive Approach: This approach shows the complete objective of the process and describes how the process will be completed.

The other options, while potentially related, represent incomplete steps or less comprehensive scenarios for the author's overall "gut feeling" about how this research will progress. This answer is thus the best indicator of the author's intuitive expectation about the final result.
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Question: 6

Which of the following words aptly substitutes ‘flummox’ as used in the passage?

Updated On: Jan 13, 2026
  • Control
  • Petrify
  • Bewilder
  • Challenge
  • Demystify
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The Correct Option is C

Solution and Explanation

The correct answer is option (C):
Bewilder

The correct answer is bewilder. The word "flummox" means to perplex someone greatly; to confuse or bewilder. Therefore, the word "bewilder" which means to cause someone to become perplexed and confused, is the most direct and appropriate synonym from the given options. The other options do not capture the same meaning. "Control" implies command. "Petrify" means to scare or paralyze. "Challenge" suggests a test or competition. "Demystify" means to make something clear and understandable, which is the opposite of flummox.
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Question: 7

According to the passage, which of the following statements is not true?

Updated On: Mar 23, 2026
  • Thomas Hardy’s poem, Heredity, reflects the DNA in a human being’s genome
  • Creating life in a lab will surely raise pertinent questions pertaining to ethics
  • Scientists, in future, will be able to create life under artificial conditions
  • Cloning of Dolly, the sheep, has invited the wrath of people because the sheep soon died a miserable death
  • Two centuries ago, urea was synthesized in a chemical laboratory
Show Solution

The Correct Option is D

Solution and Explanation

The correct answer is option (D):
Cloning of Dolly, the sheep, has invited the wrath of people because the sheep soon died a miserable death

The correct answer is "Cloning of Dolly, the sheep, has invited the wrath of people because the sheep soon died a miserable death".

This statement is not necessarily true based on general knowledge or common understanding, and is likely contradicted by information in a related passage, or at least not the primary reason people were concerned. While Dolly did have health problems and a shorter lifespan than a typical sheep, the primary source of ethical concerns and public reaction regarding Dolly's cloning wasn't solely because of her eventual health issues. Rather, the concerns were focused on the philosophical implications of cloning, the potential for genetic manipulation, and the broader questions of human interference in the natural world. Therefore, the reason provided for the people's reaction is inaccurate.

The other statements could be supported by the passage (or are general truths): the poem Heredity can be linked to genetic inheritance, creating life in a lab does raise ethical questions, scientists aiming to create life artificially is a plausible future scenario, and urea synthesis in a lab is a historical scientific event.
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Question: 8

A recently initiated technology, which is ethically acceptable, is

Updated On: Jan 13, 2026
  • Assembling the complex biological molecule
  • Gene sequencing
  • Assisted reproduction
  • Stitching together of an artificial cell
  • Inserting a proto-cell into the bacterium
Show Solution

The Correct Option is C

Solution and Explanation

The correct answer is option (C):
Assisted reproduction

The correct answer is assisted reproduction. Let's break down why and briefly look at the other options.

Assisted reproduction encompasses a range of medical techniques designed to help individuals or couples conceive a child. These include procedures like in-vitro fertilization (IVF), artificial insemination, and the use of fertility drugs. Generally, these technologies are considered ethically acceptable, especially when used to address infertility issues, and are widely practiced around the world. There are, of course, ongoing ethical considerations regarding things like embryo selection, the rights of frozen embryos, and the use of these technologies by single individuals or same-sex couples, but the core practice is widely accepted.

Now, let's examine why the other options are less appropriate:

Assembling the complex biological molecule: This is a very broad description, but the level of complexity suggested often leans into areas of synthetic biology and potentially genetic engineering. Depending on the molecule and the purpose, it might raise significant ethical concerns regarding safety, potential misuse, and unforeseen ecological consequences. While research in this area is ongoing, it's not universally accepted as ethically straightforward.

Gene sequencing: Gene sequencing, specifically for diagnostic purposes or for disease risk prediction, is generally ethically acceptable and is an increasingly common practice. However, the question asks for the *initiated* technology. While gene sequencing itself isn't new, the application of gene sequencing to design and build novel genetic sequences would be an example of initiating a new technology with many unresolved ethical questions.

Stitching together of an artificial cell: This technology pushes into the realm of synthetic biology. While there is research in the area, creating fully artificial cells that can replicate and function independently opens up many ethical questions about unintended consequences, the potential for harm, and the very definition of life itself. It's a field with significant ethical debates.

Inserting a proto-cell into the bacterium: This also delves into the complex realm of synthetic biology and genetic modification. The ethical considerations are similar to "Stitching together of an artificial cell." The potential risks and unintended consequences, the question of informed consent, and the ecological impacts are all subjects of ongoing ethical debate.
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Question: 9

According to the author’s opinion, what would be the result of cloning a human being?

Updated On: Jan 13, 2026
  • It will invite people’s indignation
  • It would be a wonderful prospect for humanity
  • It might change the face of the earth
  • It will be looked down as a sin
  • It will prove to be a global catastrophe
Show Solution

The Correct Option is A

Solution and Explanation

The correct answer is option (A):
It will invite people’s indignation

The correct answer is "It will invite people’s indignation" because the author's opinion, based on general societal reactions, would likely view human cloning with disapproval and strong negative feelings. This aligns with the common ethical and moral concerns surrounding the practice, making "indignation" (strong displeasure at something considered unjust, offensive, or insulting) the most appropriate and likely outcome according to the author's perceived perspective of societal opinion. The other options, such as "a wonderful prospect," "change the face of the earth," "looked down as a sin," and "a global catastrophe," could possibly be outcomes depending on the author's opinion and perspective, however, "indignation" best represents the general reaction from the author's likely position.
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