Step 1: Fix M first.
M has to be the first letter, so that spot is used up.
Step 2: Fill the rest one at a time.
The remaining 5 spots take the letters C, U, S, T, O in some order: 5 choices for spot 2, then 4, then 3, then 2, then 1.
Step 3: Multiply the choices.
\( 5 \times 4 \times 3 \times 2 \times 1 = 120 \).
\[ \boxed{120} \]