Question:easy

HLA-B27 is usually detected in all of the following conditions EXCEPT

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Three of the four options belong to the same family of seronegative joint diseases — one does not.
Updated On: Jul 16, 2026
  • Systemic lupus erythematosus
  • Ankylosing spondylitis
  • Psoriatic arthritis
  • Reactive arthritis
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The Correct Option is A

Solution and Explanation

This question is really asking you to separate the seronegative spondyloarthropathies from the autoimmune connective tissue diseases.

  1. Systemic lupus erythematosus: correct answer — it is a connective tissue disease tied to HLA-DR2/DR3 and autoantibodies, not HLA-B27.
  2. Ankylosing spondylitis: wrong choice for the exception — this is the prototype HLA-B27 disease.
  3. Psoriatic arthritis: wrong choice — its axial form is HLA-B27 linked.
  4. Reactive arthritis: wrong choice — post-infectious reactive arthritis is a classic HLA-B27 association.

Correct answer: Systemic lupus erythematosus.

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