Question

H and L (lymphocytic and histiocytic) cells are seen in which type of Hodgkin lymphoma?

• A. Mixed cellularity Hodgkin
• B. Lymphocyte depleted
• C. Lymphocyte predominance
• D. Nodular sclerosis

Hint:

Popcorn (L&H) cells instead of Reed-Sternberg cells point to which subtype?

Answer 1

The Correct Option is C

Step 1: Split Hodgkin lymphoma into its two big families: classical HL and the nodular lymphocyte-predominant form. Step 2: The defining cell of classical HL is the Reed-Sternberg cell, present in the mixed cellularity, lymphocyte-depleted and nodular sclerosing subtypes. Step 3: The lymphocyte-predominant subtype is the odd one out - it lacks classic RS cells and instead displays $L\&H$ (lymphocytic and histiocytic) popcorn cells with a multilobated nucleus. Step 4: Matching the H and L cell description to this subtype gives lymphocyte predominance Hodgkin lymphoma.\[\boxed{\text{Lymphocyte predominance}}\]