Question:hard
Glutathione requires which vitamin to act as an antioxidant?
Glutathione requires which vitamin to act as an antioxidant?
Show Hint
Glutathione reductase needs NADPH, which is built from this B vitamin.
Updated On: Jun 24, 2026
- Vitamin E
- Niacin
- Vitamin C
- Vitamin A
Show Solution
The Correct Option is B
Solution and Explanation
Step 1: The antioxidant role of glutathione depends not on a single use but on its continuous recycling between reduced and oxidised forms.
Step 2: When GSH scavenges peroxides via glutathione peroxidase it is spent into GSSG. Glutathione reductase restores the reduced pool, and the hydrogen needed for this reduction comes from NADPH.
Step 3: NADPH is the phosphorylated nicotinamide nucleotide whose vitamin precursor is niacin. Therefore niacin underpins the entire regeneration loop that lets glutathione keep acting as an antioxidant.
Step 4: Although vitamin C and vitamin E are standalone antioxidants, neither feeds the glutathione reductase reaction, and vitamin A has no part here, so option b is the right choice.
\[\boxed{\text{Niacin}}\]
Step 2: When GSH scavenges peroxides via glutathione peroxidase it is spent into GSSG. Glutathione reductase restores the reduced pool, and the hydrogen needed for this reduction comes from NADPH.
Step 3: NADPH is the phosphorylated nicotinamide nucleotide whose vitamin precursor is niacin. Therefore niacin underpins the entire regeneration loop that lets glutathione keep acting as an antioxidant.
Step 4: Although vitamin C and vitamin E are standalone antioxidants, neither feeds the glutathione reductase reaction, and vitamin A has no part here, so option b is the right choice.
\[\boxed{\text{Niacin}}\]
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