Question:medium
Glanzmann thrombasthenia is due to which of the following?
Glanzmann thrombasthenia is due to which of the following?
Show Hint
Defective fibrinogen receptor blocks platelet aggregation.
Updated On: Jun 23, 2026
- Decreased GpIb
- Decreased GpIIb/IIIa
- Anti-GpIIb/IIIa antibodies
- Inhibition or deficiency of ADAMTS 13
Show Solution
The Correct Option is B
Solution and Explanation
Step 1: Frame the disease by its key step in haemostasis. Glanzmann thrombasthenia breaks the aggregation phase of platelets, not adhesion.
Step 2: Aggregation needs fibrinogen bridges anchored to the $GpIIb/IIIa$ integrin. In this autosomal recessive disorder that integrin is deficient or non-functional.
Step 3: So platelets cannot clump even when stimulated by ADP or collagen, and the bleeding time is long while the count stays normal.
Step 4: Contrast: $GpIb$ loss is Bernard-Soulier (adhesion defect), ADAMTS-13 loss is TTP, and acquired antibodies drive ITP. Only decreased $GpIIb/IIIa$ fits.
\[\boxed{\text{Decreased GpIIb/IIIa}}\]
Step 2: Aggregation needs fibrinogen bridges anchored to the $GpIIb/IIIa$ integrin. In this autosomal recessive disorder that integrin is deficient or non-functional.
Step 3: So platelets cannot clump even when stimulated by ADP or collagen, and the bleeding time is long while the count stays normal.
Step 4: Contrast: $GpIb$ loss is Bernard-Soulier (adhesion defect), ADAMTS-13 loss is TTP, and acquired antibodies drive ITP. Only decreased $GpIIb/IIIa$ fits.
\[\boxed{\text{Decreased GpIIb/IIIa}}\]
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