Question

Given below are two statements:
Statement (I): The time of drug concentration above minimum inhibitory concentration ($T > \text{MIC}$) is important for clinical success in case of treatment with beta lactam antibiotics.
Statement (II): Carbapenems are sensitive to extended spectrum beta lactamases (ESBL).
In light of the above statements, choose the most appropriate answer from the options given below.

• A. Both Statement (I) and Statement (II) are true.
• B. Both Statement (I) and Statement (II) are false.
• C. Statement (I) is true but Statement (II) is false.
• D. Statement (I) is false but Statement (II) is true.

Hint:

Beta-lactams are time-dependent ($T > \text{MIC}$).
Aminoglycosides and Fluoroquinolones are concentration-dependent ($C_{\text{max}}/\text{MIC}$).
Carbapenems are highly stable against ESBLs.

Answer 1

The Correct Option is C