Analysis of each statement to determine accuracy:
Statement I: "In the nephron, the descending limb of loop of Henle is impermeable to water and permeable to electrolytes."
Correction: The descending limb of the loop of Henle exhibits permeability to water and relative impermeability to electrolytes. This characteristic facilitates water egress from the tubule, leading to filtrate concentration.
Statement II: "The proximal convoluted tubule is lined by simple columnar brush border epithelium and increases the surface area for reabsorption."
Correction: The proximal convoluted tubule is composed of simple cuboidal epithelium with a brush border, not columnar. The brush border enhances the surface area for reabsorption of substances into the bloodstream.
Both Statement I and Statement II exhibit factual errors:
- Statement I is factually incorrect due to the descending limb's permeability to water.
- Statement II is factually incorrect as the lining consists of simple cuboidal, not columnar, epithelium.
Conclusion: Both Statement I and Statement II are false.