Question

Given below are two statements, one is labelled as Assertion (A) and other one labelled as Reason (R).
Assertion (A) : Canine atopic dermatitis is characterized as a genetically predisposed tendency to develop IgE antibodies to environmental allergens, leading to a characteristic inflammatory and pruritic skin disease.
Reason (R) : Abnormality in the ratio between T helper 1 (TH1) cells and T helper 2 (TH2) cells is one of the causes of atopic dermatitis in dogs
In light of the above statements, choose the correct answer from the options given below:

• A. Both (A) and (R) are true and (R) is the correct explanation of (A).
• B. Both (A) and (R) are true and (R) is NOT the correct explanation of (A).
• C. (A) is true but (R) is false.
• D. (A) is false but (R) is true.

Hint:

Remember the Th2 pathway:
Th2 bias \(\rightarrow\) IL-4 & IL-13 release \(\rightarrow\) B-cell class switching \(\rightarrow\) High IgE production \(\rightarrow\) Atopic allergy.
This immunologic cascade links the Th1/Th2 imbalance directly to the clinical features of atopic dermatitis.

Answer 1

The Correct Option is A