Question:medium
FSH and LH both are inhibited by:
FSH and LH both are inhibited by:
Show Hint
Find the ovarian hormone that feeds back on both gonadotropins, unlike inhibin (FSH only) or progesterone (LH only).
Updated On: Jun 24, 2026
- Cortisol
- Aldosterone
- Estrogen
- Progesterone
Show Solution
The Correct Option is C
Solution and Explanation
Step 1: Frame this as a feedback-loop question. We need the single ovarian hormone whose rise turns down both FSH and LH at the same time.
Step 2: Remove the adrenal steroids first. Cortisol is a glucocorticoid and aldosterone is a mineralocorticoid; neither functions as the routine feedback brake on the gonadotropins, so options a and b are out.
Step 3: Distinguish the two ovarian feedback signals that are selective. Inhibin, made by granulosa cells, dampens FSH alone and acts only on the pituitary. Progesterone preferentially dampens LH. Because each hits only one gonadotropin, progesterone cannot be the both answer.
Step 4: Estrogen is produced under combined LH and FSH drive and feeds back, at both hypothalamus and pituitary, to lower both LH and FSH. This dual suppression makes estrogen correct. (The exception is the ovulatory phase, where high steady estrogen flips to positive feedback and provokes the LH surge.)
\[\boxed{\text{Estrogen}}\]
Step 2: Remove the adrenal steroids first. Cortisol is a glucocorticoid and aldosterone is a mineralocorticoid; neither functions as the routine feedback brake on the gonadotropins, so options a and b are out.
Step 3: Distinguish the two ovarian feedback signals that are selective. Inhibin, made by granulosa cells, dampens FSH alone and acts only on the pituitary. Progesterone preferentially dampens LH. Because each hits only one gonadotropin, progesterone cannot be the both answer.
Step 4: Estrogen is produced under combined LH and FSH drive and feeds back, at both hypothalamus and pituitary, to lower both LH and FSH. This dual suppression makes estrogen correct. (The exception is the ovulatory phase, where high steady estrogen flips to positive feedback and provokes the LH surge.)
\[\boxed{\text{Estrogen}}\]
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