Rather than plugging directly into the gradient-dot-unit-vector formula, we can derive the directional derivative from first principles using a parametrized line through the point, which shows exactly why that formula works.
First, normalize the direction vector \(\vec{v}=\hat{i}+\hat{j}+2\hat{k}\): its length is \(|\vec{v}|=\sqrt{1^2+1^2+2^2}=\sqrt{6}\), so the unit vector is \(\hat{u}=\frac{1}{\sqrt{6}}(\hat{i}+\hat{j}+2\hat{k})\), with components \(u_1=\frac{1}{\sqrt{6}}\), \(u_2=\frac{1}{\sqrt{6}}\), \(u_3=\frac{2}{\sqrt{6}}\).
Now define a line through the point \(P(1,-2,-1)\) moving in this direction: \(x(t)=1+u_1t\), \(y(t)=-2+u_2t\), \(z(t)=-1+u_3t\). The directional derivative is the rate of change of \(F\) along this line at \(t=0\), i.e. \(\left.\frac{dF}{dt}\right|_{t=0}\).
By the chain rule:
\[ \frac{dF}{dt} = \frac{\partial F}{\partial x}\frac{dx}{dt}+\frac{\partial F}{\partial y}\frac{dy}{dt}+\frac{\partial F}{\partial z}\frac{dz}{dt} = (2x)(u_1)+(6y)(u_2)+(4z)(u_3) \]Evaluating at \(t=0\), i.e. at \(x=1,y=-2,z=-1\):
\[ \left.\frac{dF}{dt}\right|_{t=0} = 2(1)\left(\frac{1}{\sqrt{6}}\right)+6(-2)\left(\frac{1}{\sqrt{6}}\right)+4(-1)\left(\frac{2}{\sqrt{6}}\right) = \frac{2-12-8}{\sqrt{6}} = \frac{-18}{\sqrt{6}} = -3\sqrt{6} \]This derivation shows directly, from the definition of a directional derivative as a rate of change along a parametrized path, that the value comes out to \(-3\sqrt{6}\), built here from the chain rule instead of quoted as a formula.
Checking the other options: 18 and -18 exceed the magnitude of the gradient itself (\(|\nabla F|=\sqrt{164}\approx12.8\)), so a derivative of magnitude 18 is impossible regardless of sign; and \(3\sqrt{6}\) has the right magnitude but the wrong sign, since the derivative above came out negative.
Therefore, the correct answer is \(-3\sqrt{6}\).