Question

During which phase of mitosis do the centromeres split and chromatids move to opposite poles?

• A. Prophase
• B. Metaphase
• C. Anaphase
• D. Telophase

Hint:

*Remember:* "Anaphase = Apart." It’s when the chromatids move apart to opposite poles.

Answer 1

The Correct Option is C

To resolve the issue, it is necessary to comprehend the stages of mitosis and pinpoint the phase characterized by centromere division and chromatid migration to opposing poles.

1. Mitosis Explained:

Mitosis is the cellular process of division that results in two genetically identical daughter cells, each inheriting a complete set of the parent cell's DNA. Mitosis comprises distinct stages:

• Prophase: Chromosomes condense and spindle apparatus develops.
• Metaphase: Chromosomes are positioned along the equatorial plane of the cell.
• Anaphase: Centromeres divide, and sister chromatids are segregated towards opposite cellular extremities.
• Telophase: Chromatids arrive at the poles, and nuclear envelopes are reconstituted.

2. Critical Event Identified:

The mitotic phase marked by the splitting of centromeres and the subsequent movement of chromatids to opposite poles is definitively anaphase.

3. Rationale for Anaphase:

- During anaphase, sister chromatids separate at their centromeric connection.
- These now individual chromosomes are propelled towards opposing cell poles by the spindle fibers.
- This separation is essential for equitable distribution of chromosomes to the nascent daughter cells.

Final Answer:

The division of centromeres and the migration of chromatids to opposite poles occur during anaphase of mitosis.