Question

During healing of skin wounds, the sequence of events occurring during healing by second intention (secondary union) are:
A. Inflammatory phase
B. Initial hemorrhage
C. Granulation Issue
D. Wound Contraction
E. Epithelial Changes
Choose the correct answer from the options given below:

• A. B, A, E, C, D
• B. B, E, A, C, D
• C. B, A, C, D, E
• D. B, A, C, E, D

Hint:

In wound healing, remember: bleeding first, inflammation second, tissue formation third, contraction fourth, and epithelialization last.

Answer 1

The Correct Option is C

Step 1: Recall wound healing types.
Wound healing occurs by primary intention (clean wounds with edges closed) or secondary intention (large tissue loss, wound left open, requiring granulation). Secondary intention healing is slower and results in more scarring.
Step 2: Sequence of events in secondary intention.
1. Initial hemorrhage (B): Bleeding after injury forms a clot and fibrin.
2. Inflammatory phase (A): Neutrophils and macrophages clear debris and pathogens.
3. Granulation tissue formation (C): Fibroblasts and new capillaries fill the wound.
4. Wound contraction (D): Myofibroblasts reduce the wound size.
5. Epithelial changes (E): Epithelialization covers the wound surface.
Step 3: Analyze the options.
- Option (A) B, A, E, C, D: Incorrect; epithelialization precedes contraction.
- Option (B) B, E, A, C, D: Incorrect; epithelialization does not follow hemorrhage immediately.
- Option (C) B, A, C, D, E: Correct sequence.
- Option (D) B, A, C, E, D: Incorrect; epithelialization occurs last.
Step 4: Conclusion.
The correct sequence for secondary intention healing is: Initial Hemorrhage → Inflammatory Phase → Granulation Tissue → Wound Contraction → Epithelial Changes.